CP-456773 sodium salt
N-[[(1,2,3,5,6,7-Hexahydro-s-indacen-4-yl)amino]carbonyl]-4-(1-hydroxy-1-methylethyl)-2-furansulfonamide monosodium salt
CAS: 256373-96-3
Molecular Formula: C20H23N2NaO5S
CP-456773 sodium salt - Names and Identifiers
CP-456773 sodium salt - Physico-chemical Properties
| Molecular Formula | C20H23N2NaO5S |
| Molar Mass | 426.46179 |
| Solubility | H2O: ≥ 30 mg/mL |
| Appearance | powder |
| Color | white to beige |
| Storage Condition | room temp |
| In vitro study | MCC950 inhibits classical and non-classical NLRP3 activation with IC50 of 7.5 and 8.1 nM in bone marrow-derived macrophages and human monocyte-derived macrophages, respectively. MCC950 specifically inhibits the activation of NLRP3 and does not inhibit AIM2, NLRC4 or NLRP1 These inflammasomes. |
| In vivo study | MCC950 reduces interleukin-1β (IL-1β) production and reduces the severity of experimental autoimmune encephalomyelitis. In a mouse model of the autoinflammatory disease Cryopyrin-associated cyclic syndrome, MCC950 was able to rescue neonatal death. In indirect in vitro experiments, it was active in samples derived from patients with Veyer's syndrome. |
CP-456773 sodium salt - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.345 ml | 11.724 ml | 23.449 ml |
| 5 mM | 0.469 ml | 2.345 ml | 4.69 ml |
| 10 mM | 0.234 ml | 1.172 ml | 2.345 ml |
| 5 mM | 0.047 ml | 0.234 ml | 0.469 ml |
Last Update：2024-01-02 23:10:35
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View History
CP-456773 sodium salt
TIMTEC-BB SBB004207
1,8-Naphthyridine-1(2H)-carboxamide, N-[5-cyano-4-[(2-methoxyethyl)amino]-2-pyridinyl]-7-formyl-3,4-dihydro-6-[(4-methyl-2-oxo-1-piperazinyl)methyl]-, 2-hydroxy-1,2,3-propanetricarboxylate (1:1)
Ethanone, 1-[(1R,2S)-2-(1-methylethyl)cyclohexyl]- (9CI)
S-二苯基脯氨醇三甲基硅醚
N-[3-[(2,3-Dihydro-2-oxo-1H-indol-5-yl)oxy]-4-methylphenyl]-4-[(4-ethyl-1-piperazinyl)methyl]-3-(trifluoromethyl)benzamide
2-甲基-5-吡嗪羧酸
Neoprene emulsion adhesive
NALPHA-ACETYL-D-ARGININE DIHYDRATE
29334-07-4
TIMTEC-BB SBB004207
1,8-Naphthyridine-1(2H)-carboxamide, N-[5-cyano-4-[(2-methoxyethyl)amino]-2-pyridinyl]-7-formyl-3,4-dihydro-6-[(4-methyl-2-oxo-1-piperazinyl)methyl]-, 2-hydroxy-1,2,3-propanetricarboxylate (1:1)
Ethanone, 1-[(1R,2S)-2-(1-methylethyl)cyclohexyl]- (9CI)
S-二苯基脯氨醇三甲基硅醚
N-[3-[(2,3-Dihydro-2-oxo-1H-indol-5-yl)oxy]-4-methylphenyl]-4-[(4-ethyl-1-piperazinyl)methyl]-3-(trifluoromethyl)benzamide
2-甲基-5-吡嗪羧酸
Neoprene emulsion adhesive
NALPHA-ACETYL-D-ARGININE DIHYDRATE
29334-07-4